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| 218 BC |
| | | Hannibal crosses the Alps with his elephants, beginning the Second Punic War | |
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| 217 BC |
| | | Hannibal surprises and traps a Roman army on a narrow plain beside Lake Trasimene | |
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| 216 BC |
| | | Hannibal destroys a Roman army at Cannae, in the most severe defeat ever suffered by Rome | |
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| 202 BC |
| | | Hannibal suffers his first decisive defeat by a Roman army, at an unidentified site in north Africa called Zama | |
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| 201 BC |
| | | Carthaginian Spain is handed over to Rome to become two new provinces, at the end of the Second Punic War | |
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| 149 BC |
| | | Rome picks a quarrel with Carthage to begin the Third Punic War | |
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| 146 BC |
| | | Carthage is destroyed by the Romans at the end of the Third Punic War | |
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